For Research Use Only
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondria-derived peptide encoded within the 12S ribosomal RNA gene of the mitochondrial genome. It represents a novel class of peptide signaling molecules known as mitochondrial-derived peptides (MDPs), which are distinct from nuclear-encoded peptides in their origin and regulatory function. Research has investigated MOTS-c for its role in regulating metabolic homeostasis, with studies demonstrating its ability to activate AMPK signaling pathways and enhance insulin sensitivity in skeletal muscle tissue. It has also been studied for its potential involvement in mitochondrial biogenesis, cellular stress response, and the regulation of glucose and lipid metabolism. More recently, research has explored MOTS-c as a potential mediator of exercise-induced metabolic adaptation and longevity signaling, with circulating levels observed to decline with age in animal models.
Specifications
| Format |
Lyophilized powder |
| Molecular Formula |
C₁₀₁H₁₈₀N₃₄O₂₉S |
| Purity |
≥ 99% (HPLC verified) |
| Appearance |
White/off-white powder |
| Storage |
Store at −20 °C (lyophilized); refrigerate after reconstitution |
| Packaging |
Sterile, sealed 40 mg vial |
Intended Use
This compound is provided exclusively for laboratory research purposes, including studies on mitochondrial signaling, metabolic regulation, AMPK pathway activation, insulin sensitivity, and mitochondria-derived peptide biology. It is not approved for human consumption, medical, veterinary, or diagnostic use.
Important Notice
- Not for human or animal use
- Not for therapeutic or diagnostic applications
- Handle only by qualified laboratory professionals
